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. 2018 Sep 6;218(Suppl 5):S438–S447. doi: 10.1093/infdis/jiy457

Figure 6.

Figure 6.

Levels of messenger RNA transcripts in Marburg virus (MARV) Musoke-infected STAT2 knockout (KO) hamsters. Reverse-transcription polymerase chain reaction analysis of transcripts isolated from livers and spleens of infected hamsters at the indicated day after infection. Up-regulation of chemokines, proinflammatory, and anti-inflammatory cytokines is evident. Liver is a primary target of MARV infection, and the activation of immune cells strongly affects the spleen during replication. Abbreviations: IFN, interferon; IL-1β, IL-2, IL-4, IL-5, IL-6, IL-10, and IL-12, interleukin 1β, 2, 4, 5, 6, 10, and 12; IP-10, IFN-inducible protein 10; MIP-1α, macrophage inflammatory protein 1α; MX2, myxovirus resistance 2; TNF-α, tumor necrosis factor-α.