Table 2.
Significance of different model terms appearing in the final model for each response, together with models evaluation.
| Component |
p-Value |
|||
|---|---|---|---|---|
| SM (mg/mL) | PS (nm) | PDI | ZP (mV) | |
| A | <0.0001 | <0.0001 | 0.0062 | <0.0001 |
| B | – | 0.1209 | – | 0.0041 |
| C | <0.0001 | <0.0001 | <0.0001 | 0.0709 |
| AB | – | – | – | 0.0056 |
| AC | 0.0119 | 0.021 | – | <0.0001 |
| BC | – | – | – | <0.0001 |
| ABC | – | – | 0.0597 | – |
| RMSE | 0.33 | 0.73 | 0.03 | 2.15 |
| R2 | 0.9782 | 0.9683 | 0.8322 | 0.9448 |
| Adjusted R2 | 0.9722 | 0.9572 | 0.7855 | 0.9094 |
| Prediction R2 | 0.9613 | 0.9369 | 0.7016 | 0.8379 |
| PRESS | 3.48 | 18.21 | 0.029 | 190.04 |
| Adeq Precision | 34.505 | 28.293 | 12.64 | 15.189 |
A: Auxiliary surfactant type; B: Penetration enhancer type; C: Total surfactants: drug ratio; SM: solubility of STZ in MMs; PS: particle size; PDI: polydispersity index; ZP: zeta potential; RMSE: Root mean square error; R2: Regression coefficient.
*
p Values for significant terms are shown in bold face.