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. 2018 Jul 19;218(Suppl 5):S423–S433. doi: 10.1093/infdis/jiy367

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Published by Oxford University Press for the Infectious Diseases Society of America 2018.

This work is written by (a) US Government employee(s) and is in the public domain in the US.

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Figure 5. — Marburg virus (MARV)–induced changes in mammary glands and tongue. A, In the mammary gland, low numbers of degenerate and apoptotic acinar cells are present with rare viral intracytoplasmic inclusion bodies (arrows) (hematoxylin-eosin staining). B, Immunostaining of MARV glycoprotein (GP) labels mammary acinar and ductal epithelial cells, interstitial fibroblasts, and macrophages (3,3′-diaminobenzidine [DAB] chromagen and hematoxylin counterstain). C, Abundant MARV genome is demonstrated by in situ hybridization in the cells and secretions of the mammary gland (red substrate chromagen and hematoxylin counterstain). D, Within the circumvallate papilla (tongue), numerous apoptotic cells are within the taste bud and the surface stratified squamous epithelium (Civatte bodies). E, F, Neurosensory cells of the taste bud and epithelial cells of the epithelium immunolabel for MARV GP and genome.