Table 2.
Mean particle size, polydispersity index (PDI), zeta potential (ζ), encapsulation efficiency (EE%) and loading capacity (LC%) of different NLC formulations (see Table 1 for their composition).
| Formulation | size (nm) | PDI | ζ (mV) | EE% | LC% |
|---|---|---|---|---|---|
| NLC1A empty | 571.3 ± 30.6 | 0.30 ± 0.02 | −25.2 ± 0.4 | – | – |
| NLC1A | 605.6 ± 12.1 | 0.33 ± 0.05 | −29.0 ± 0.5 | 73.4 ± 2.4 | 2.9 ± 0.3 |
| NLC2A empty | 367.4 ± 2.8 | 0.29 ± 0.02 | −38.7 ± 0.9 | – | – |
| NLC2A | 368.4 ± 7.6 | 0.24 ± 0.03 | −40.8 ± 0.3 | 53.9 ± 0.1 | 2.1 ± 0.1 |
| NLC1B empty | 483.6 ± 23.4 | 0.49 ± 0.03 | −35.0 ± 0.6 | – | – |
| NLC1B | 650.6 ± 15.3 | 0.62 ± 0.13 | −37.6 ± 0.5 | 79.1 ± 0.6 | 3.2 ± 0.3 |
| NLC2B empty | –a | – | – | – | – |
| NLC2B | – | – | – | – | – |
| NLC1C empty | 591.1 ± 22.0 | 0.42 ± 0.08 | −35.3 ± 0.8 | – | – |
| NLC1C | 563.3 ± 3.7 | 0.36 ± 0.03 | −31.6 ± 1.6 | 80.0 ± 0.2 | 3.2 ± 0.0 |
| NLC2C empty | 365.1 ± 1.6 | 0.24 ± 0.04 | −42.4 ± 0.4 | – | – |
| NLC2C | 405.4 ± 3.8 | 0.22 ± 0.02 | −38.8 ± 1.4 | 40.1 ± 3.2 | 1.6 ± 0.1 |
agelification occurred.