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. 2018 Nov 14;38(11):469–479. doi: 10.1089/jir.2018.0066

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© Sophie Jacobs et al. 2018; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FIG. 6. — Detection of type III IFN in biological samples by ELISA and bioassay. (A, B) IFN-λ2/3 detection by ELISA (A) and bioassay (B) in the serum of AG129 mice 2 or 4 days after electroinjection of mouse IFN-λ3 (mIFN-λ3) expressing (pCS59) or empty (pcDNA3) plasmids, 2 days after injection of pCS59, or 3 days after infection with mouse norovirus. IFN-λ detection in the serum by ELISA was performed without UV exposure to keep maximal sensitivity. (C, D) IFN-λ2/3 detection by ELISA (C) and bioassay (D) in the bronchoalveolar lavage of BALB/C mice, 5 days postinfection with RSV, compared to control mice (mock). BALF were UV-exposed before testing. (A–D) The horizontal dotted line represents the LOD. Mann–Whitney: */**indicates a significant difference compared to pcDNA3 group at days 2 or 4 (A, B) or compared to mock (D). BALF, bronchoalveolar lavage fluid; RSV, respiratory syncytial virus.