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IFN-λ sequence alignments. Sequences of human and mouse IFN-λ regions implicated in receptor binding were aligned. Key amino acid residues involved in receptor activation that differs between mouse and human IFN-λ2 and IFN-λ3 sequences are indicated in bold in mouse sequences. Residues unique to mouse IFN-λ3 in helices A and F are indicated in bold red. *Indicates identical amino acids between human IFN-λ3 and IFN-λ4. Color images available online at www.liebertpub.com/jir
