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FG-3019, an anti–connective tissue growth factor antibody, decreased depression-like behavior. (A) Acute administration of FG-3019 decreased time spent immobile and increased time spent swimming in the forced swim test. n = 11–12 per group. All values are mean ± SEM. *p < .05. (B) Chronic administration of FG-3019 decreased time spent immobile and increased time spent climbing in the forced swim test. n = 7–8 per group. All values are mean 6 SEM. ***p < .001.
