Fig. 2.

MSC-exo increased male to male social interaction and repetitive behaviors during social interaction. Each group was tested for basal behaviors (gray) and was re-tested 3 weeks after treatment (saline or MSC-exo, black). a Intra-subject comparison showed that the BTBR MSC-exo group had spent a significantly longer time engaging in social interaction with other stranger male mice (paired T-test). Inter-group comparison showed that the BTBR MSC-exo group had spent significantly more time engaging in social interaction compared to BTBR saline (ANOVA1, Bonferroni). b Intra-subject comparison of BTBR MSC-exo group had spent significantly less time in repetitive behaviors (paired T test). Inter-group comparison showed BTBR MSC-exo is not significantly different than both BTBR saline and C57BL saline groups in time spent in repetitive behaviors. (ANOVA1, Bonferroni). The data is presented as mean + SEM. ***p < 0.001