Table 4.
Functional pathways altered in transcriptome and proteome analyses in KEGG database
| Pathway | Genes | Official gene symbol | Fold change | P-value | TNC |
|---|---|---|---|---|---|
| Transcriptomic | |||||
| hsa04080: neuroactive ligand–receptor interaction | 18 | GABRG1, GABRD, GABRG2, GABRA2, GABRA1, CCKBR, GRIN1, OXTR, GABBR2, GRM1, GRIN2C, SSTR1, PRSS2, PRSS3, ADRA1B, HTR5A, F2R, HTR2A | 3.69 | < 0.01 | 3103 |
| hsa04020: calcium signaling pathway | 14 | CCKBR, GRIN1, OXTR, ITPKA, GRM1, ATP2B3, GRIN2C, ADRA1B, RYR2, CAMK2B, CAMK2A, HTR5A, F2R, HTR2A | 4.17 | < 0.01 | 3111 |
| hsa04512: ECM-receptor interaction | 10 | IBSP, COL4A2, COL4A1, CD44, TNC, COL3A1, COL1A2, SV2B, COL1A1, FN1 | 6.24 | < 0.01 | 3125 |
| hsa00910: nitrogen metabolism | 4 | GLS2, CA9, CA12, GLS | 9.12 | 0.19 | 3076 |
| hsa04720: long-term potentiation | 6 | GRIN2C, PPP1R1A, GRIN1, CAMK2B, CAMK2A, GRM1 | 4.63 | 0.15 | 3157 |
| hsa05014: amyotrophic lateral sclerosis | 5 | SLC1A2, GRIN2C, GRIN1, NEFH, NEFL | 4.95 | 0.24 | 3125 |
| hsa04510: focal adhesion | 9 | IBSP, PAK6, COL4A2, COL4A1, TNC, COL3A1, COL1A2, COL1A1, FN1 | 2.35 | 0.38 | 3103 |
| hsa00471: d-glutamine and d-glutamate metabolism | 2 | GLS2, GLS | 26.21 | 0.59 | 3333 |
| Proteomic | |||||
| hsa05130: pathogenic Escherichia coli infection | 5 | ACTB, TUBB2A, TUBB2C, TUBB4, YWHAZ | 19.39 | 0.00 | 30 |
| hsa00010: glycolysis/gluconeogenesis | 4 | ALDOA, PGAM1, HK1, ENO1 | 14.74 | 0.04 | 30 |
TNC total number of components in each pathway