Table 1.
Minimal inhibitory concentration (MIC) of ceftazidime-avibactam against KPC-2 or OXA-232 carbapenemase-producing Klebsiella pneumoniae
| Strain no. | Bacteria | β-lactamase | MIC (mg/L) | Associated β-lactamase | |||
|---|---|---|---|---|---|---|---|
| CAZ-AVI | CAZ | IPM | MEM | ||||
| R16- Hefei | K. pneumoniae | KPC-2 | 8 | 128 | 64 | 64 | CTX-M-14, SHV-11, DHA-1 |
| R18- Hefei | K. pneumoniae | KPC-2 | 4 | 128 | 8 | 16 | SHV-28, DHA-1 |
| R19- Hefei | K. pneumoniae | KPC-2 | 4 | 128 | 16 | 16 | SHV-12, DHA-1 |
| R31- Beijing | K. pneumoniae | KPC-2 | 8 | 128 | 64 | 256 | SHV-11, DHA-1 |
| R35- Beijing | K. pneumoniae | KPC-2 | 8 | 128 | 128 | 256 | SHV-11, DHA-1 |
| R39-Fuzhou | K. pneumoniae | KPC-2 | 8 | > 256 | 32 | 64 | CTX-M-14, SHV-12, DHA-1 |
| R42- Fuzhou | K. pneumoniae | KPC-2 | 8 | > 256 | 32 | 64 | CTX-M-14, SHV-12, DHA-1 |
| R44- Fuzhou | K. pneumoniae | KPC-2 | 8 | > 256 | 64 | 128 | CTX-M-14, SHV-12, DHA-1 |
| R46- Fuzhou | K. pneumoniae | KPC-2 | 8 | > 256 | 64 | 64 | SHV-12, DHA-1 |
| R52- Fuzhou | K. pneumoniae | KPC-2 | 8 | > 256 | 64 | 128 | CTX-M-14, SHV-12, DHA-1 |
| R53- Fuzhou | K. pneumoniae | KPC-2 | 8 | > 256 | 64 | 128 | CTX-M-14, SHV-12, DHA-1 |
| R59- Hangzhou | K. pneumoniae | KPC-2 | 8 | 32 | 8 | 16 | CTX-M-14, SHV-11, DHA-1 |
| R60- Hangzhou | K. pneumoniae | KPC-2 | 4 | 32 | 4 | 4 | CTX-M-14, SHV-11, DHA-1 |
| JSD-Shanghai | K. pneumoniae | KPC-2 | 8 | 128 | 128 | 512 | CTX-M-14, SHV-11, DHA-1 |
| WJQ-Shanghai | K. pneumoniae | KPC-2 | 8 | > 256 | 128 | 256 | CTX-M-14, SHV-11, DHA-1 |
| LDX-Shanghai | K. pneumoniae | KPC-2 | 8 | > 256 | 32 | 64 | CTX-M-55, SHV-31, DHA-1 |
| PED-Shanghai | K. pneumoniae | OXA-232 | 2 | > 32 | 1 | 4 | CTX-M-15, SHV-1 |
Note: CAZ-AVI Ceftazidime-avibactam, CAZ Ceftazidime, IPM Imipenem, MEM Meropenem