Table 2.
Results of MIC and antimicrobial susceptibility testing of ceftazidime-avibactam single dosing and combined with aztreonam against NDM + KPC-2 carbapenemase-producing Klebsiella pneumoniae in 30 strains
| Strain no. | Bacteria | β-lactamase | MIC(mg/L) single dosing | MIC(mg/L) Combined dosing | FIC value | Associated β-lactamase | ||
|---|---|---|---|---|---|---|---|---|
| ATM | CAZ-AVI | ATM | CAZ-AVI | ATM + CAZ-AVI | ||||
| R078 Anhui | K. pneumoniae | NDM | 256 | 32 | 8 | 1 | 0.06 | SHV-28, DHA-1, CTX-M-15 |
| R080 Hainan | K. pneumoniae | NDM | 128 | 4 | 32 | 0.25 | 0.31 | SHV-11, DHA-1, CTX-M-14 |
| R081 Hainan | K. pneumoniae | NDM | 1024 | 8 | 64 | 2 | 0.31 | SHV-11, DHA-1, CTX-M-14 |
| R082 Hainan | K. pneumoniae | NDM | 256 | 64 | 16 | 1 | 0.08 | SHV-11, DHA-1, CTX-M-15, CTX-M-14 |
| R083 Hainan | K. pneumoniae | NDM | 128 | 64 | 32 | 0.5 | 0.26 | SHV-12, DHA-1, CTX-M-15 |
| R084 Hainan | K. pneumoniae | NDM | 512 | 64 | 16 | 1 | 0.05 | SHV-12, DHA-1 |
| R085 Hainan | K. pneumoniae | NDM | 1024 | 128 | 32 | 2 | 0.05 | SHV-12, DHA-1, CTX-M-15 |
| R086 Hainan | K. pneumoniae | NDM | 128 | 64 | 16 | 0.5 | 0.13 | SHV-12, DHA-1, CTX-M-15 |
| R088 Hainan | K. pneumoniae | NDM | 32 | 2 | 4 | 0.5 | 0.38 | SHV-11, DHA-1, CTX-M-14 |
| R093 Hebei | K. pneumoniae | NDM | 32 | 64 | 4 | 0.5 | 0.13 | SHV1, DHA-1, CTX-M-14 |
| R094 Hebei | K. pneumoniae | NDM | 32 | 64 | 8 | 0.25 | 0.25 | SHV-12, DHA-1, CTX-M-14 |
| R095 Hebei | K. pneumoniae | NDM | 32 | 2 | 8 | 0.25 | 0.38 | SHV-12, DHA-1, CTX-M-15 |
| R096 Henan | K. pneumoniae | NDM | 16 | 64 | 16 | 0.5 | 1.01 | SHV1, DHA-1, CTX-M-15 |
| R097 Henan | K. pneumoniae | NDM | 8 | 256 | 4 | 128 | 1.00 | SHV1, DHA-1, CTX-M-14 |
| R098 Henan | K. pneumoniae | NDM | 256 | 64 | 32 | 1 | 0.14 | DHA-1 |
| R100 Shanxi | K. pneumoniae | NDM | 8 | 32 | 4 | 32 | 1.50 | SHV-78, DHA-1, CTX-M-14 |
| R101 Shanxi | K. pneumoniae | NDM | 256 | 128 | 16 | 1 | 0.07 | SHV-78, DHA-1, CTX-M-14 |
| R102 Shanxi | K. pneumoniae | NDM | 32 | 256 | 4 | 1 | 0.13 | SHV-78, DHA-1, CTX-M-14 |
| R103 Shanxi | K. pneumoniae | NDM | 128 | 64 | 32 | 0.25 | 0.25 | SHV1, DHA-1, CTX-M-15 |
| R106 Sanxi | K. pneumoniae | NDM | 128 | 64 | 8 | 1 | 0.08 | SHV-12, DHA-1 |
| R110 Sanxi | K. pneumoniae | NDM | 128 | 256 | 8 | 1 | 0.07 | SHV-12, DHA-1 |
| R113 Sanxi | K. pneumoniae | NDM | 128 | 64 | 16 | 0.5 | 0.13 | SHV-12, DHA-1 |
| R122 Tianjin | K. pneumoniae | NDM | 32 | 1 | 4 | 0.25 | 0.38 | SHV-12, DHA-1, CTX-M-14 |
| R126 Tianjin | K. pneumoniae | NDM | 512 | 64 | 16 | 1 | 0.05 | SHV-12, DHA-1, CTX-M-14 |
| R127 Tianjin | K. pneumoniae | NDM | 256 | 128 | 32 | 1 | 0.13 | SHV2, DHA-1 |
| R128 Zhejiang | K. pneumoniae | NDM | 128 | 256 | 8 | 2 | 0.07 | SHV1, DHA-1 |
| R129 Zhejiang | K. pneumoniae | NDM | 4 | 0.5 | 0.5 | 0.125 | 0.38 | SHV-12, DHA-1, CTX-M-15 |
| R136 Zhejiang | K. pneumoniae | NDM | 256 | 64 | 16 | 1 | 0.08 | SHV-12, DHA-1 |
| R148 Tianjing | K. pneumoniae | KPC-2,NDM | 2048 | 8 | 256 | 2 | 0.38 | SHV-12, DHA-1, CTX-M-14 |
| R153 Henan | K. pneumoniae | KPC-2,NDM | 2048 | 128 | 128 | 8 | 0.13 | SHV-12, DHA-1 |