Table 5.
Effect of rutin on Antioxidant enzyme status and oxidative stress marker level in Cisplatin treated rats testis
| Groups (n = 4) | CAT (U/mg protein) |
SOD (U/mg protein) |
POD (nmole/mg protein) |
GSR (nM NADPH oxidized/min/mg tissue) |
TBARS (nM/mg tissue) |
|---|---|---|---|---|---|
| Control | 31.04 ± 2.96 | 29.75 ± 0.61 | 10.00 ± 1.33 | 28.21 ± 0.84 | 2.58 ± 0.75 |
| Cisplatin | 17.20 ± 1.91a** | 17.90 ± 0.61a** | 1.98 ± 0.25a*** | 14.60 ± 0.67a** | 10.27 ± 0.74a*** |
| Cisplatin + Rutin | 28.23 ± 1.79b* | 19.19 ± 1.48a* | 6.68 ± 0.69a*b** | 18.86 ± 1.30a* | 7.46 ± 0.77ab** |
| Rutin | 23.15 ± 0.87 | 29.36 ± 3.48c* | 7.82 ± 0.98 | 28.09 ± 2.67c* | 3.06 ± 0.50c** |
Values are expressed as mean ± SEM *p < 0.05, **p < 0.01, ***p < 0.001, a = Value vs control, b = Value vs cisplatin, c = Value vs Cisplatin+Rutin