Table 2.

Uni-and Multivariate analyses of predictors of postoperative recurrence in training and validation cohorts

Variables		Training cohort						Validation cohort
		Univariate			Multivariate			Multivariate
		HR	95%CI	p	HR	95%CI	p	HR	95%CI	p
Gender	Male	1.131	0.672–1.903	0.642	\	\	\	\	\	\
	Female
Tumor size	≤3 cm	1.831	1.190–2.817	0.006	\	\	0.193	\	\	0.167
	> 3 cm
Vascular invasion	Present	2.364	1.341–4.166	0.003	2.602	1.408–4.807	0.002	\	\	0.141
	Absent
Microvascular invasion	Present	1.285	0.858–1.926	0.223	\	\	\	\	\	\
	Absent
Differentiation	III-IV	1.242	0.871–1.772	0.231	\	\	\	\	\	\
	I-II
Liver Cirrhosis	YES	1.076	0.89–1.301	0.451	\	\	\	\	\	\
	NO
HBsAg	Positive	1.292	0.747–2.233	0.359	\	\	\	\	\	\
	Negative
Tumor encapsulation	Present	1.533	1.032–2.277	0.034	1.637	1.074–2.494	0.022	\	\	0.975
	Absent
Rad-score	≤4.32	1.779	1.174–2.703	0.007	1.558	1.022–2.375	0.039	1.890	1.041–3.436	0.036
	> 4.32
DBIL, μmol/L		1.002	0.986–1.019	0.797	\	\	\	\	\	\
TBIL, μmol/L		1.003	0.99–1.015	0.691	\	\	\	\	\	\
ALT, U/L		1.001	0.998–1.004	0.624	\	\	\	\	\	\
AST, U/L		1.001	0.999–1.004	0.339	\	\	\	\	\	\
AFP, ng/ml		1.000	1.000–1.000	0.494	\	\	\	\	\	\
ALB, g/L		1.020	0.986–1.055	0.253	\	\	\	\	\	\
GGT, U/L		1.002	1.001–1.004	0.002	1.002	1.000–1.003	0.017	\	\	0.426

Abbreviations: ALB Albumin, ALT Alanine aminotransferase, AST Aspartate aminotransferase, DBIL Direct Bilirubin, TBIL Total bilirubin; GGT γ-Glutamyltransferase, AFP Alpha-fetoprotein