Table 4.
C-indices of rad-score based nomograms, clinicopathological nomograms and traditional staging systems
| Training cohort | Validation cohort | |||||||
|---|---|---|---|---|---|---|---|---|
| TTR | OS | TTR | OS | |||||
| C-index | 95%CI | C-index | 95%CI | C-index | 95%CI | C-index | 95%CI | |
| Rad-score | 0.563 | 0.516–0.610 | 0.541 | 0.488–0.594 | 0.555 | 0.491–0.619 | 0.629 | 0.529–0.729 |
| Rad-score based nomograms | 0.639 | 0.577–0.701 | 0.714 | 0.635–0.793 | 0.587 | 0.479–0.695 | 0.710 | 0.602–0.818 |
| Clinical-pathological nomograms | 0.633 | 0.571–0.695 | 0.554 | 0.485–0.623 | 0.601 | 0.592–0.610 | 0.642 | 0.532–0.752 |
| Rad-score-TNM nomogram | 0.584 | 0.531–0.637 | 0.626 | 0.549–0.703 | 0.601 | 0.530–0.672 | 0.617 | 0.507–0.727 |
| Rad-score-BCLC nomogram | 0.580 | 0.526–0.634 | 0.627 | 0.549–0.705 | 0.601 | 0.523–0.679 | 0.622 | 0.509–0.735 |
| Traditional staging system | ||||||||
| TNM | 0.552 | 0.513–0.581 | 0.575 | 0.515–0.635 | 0.553 | 0.499–0.607 | 0.521 | 0.453–0.589 |
| BCLC | 0.547 | 0.506–0.588 | 0.574 | 0.511–0.637 | 0.548 | 0.485–0.611 | 0.506 | 0.420–0.592 |
| JIS | 0.554 | 0.508–0.600 | 0.601 | 0.533–0.669 | 0.564 | 0.503–0.625 | 0.574 | 0.504–0.644 |
| HKLC | 0.575 | 0.529–0.631 | 0.628 | 0.620–0.636 | 0.582 | 0.507–0.657 | 0.596 | 0.487–0.701 |
Abbreviation: TNM Tumor–node–metastasis, BCLC Barcelona Clinic Liver Cancer stage system, JIS Japan Integrated Staging, HKLC Hong Kong Liver Cancer staging score