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. 2018 Nov 21;22:319. doi: 10.1186/s13054-018-2247-y

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Colistin, piperacillin-tazobactam, and meropenem consumption (defined daily dose/100 bed days) before and after intervention in the intensive care unit (left panel) and in the medical and surgical departments (right panel). *p < 0.05 for comparison with preintervention period