Fig. 6.

A schematic of multiplex RNA detection using surface plasmon resonance imaging (SPRi). A schematic of multiplex RNA detection using surface plasmon resonance imaging (SPRi). RNA fragments are first extracted from bacteria of interest (a). A biochip functionalized with three specific capture probes (CP) and a negative control probe (NP), each demarcated in a unique color (b (i)) is shown to exhibit no change in reflectivity (c (i)). Upon introduction to the RNA (b (ii)), there is an increase in single (c (ii)). Finally, gold nanoparticles functionalized with the detection probe (GNP-DP) are introduced and shown to enhance the change in reflectivity

(Adapted with permission from Melaine et al. [139]. Copyright 2017 American Chemical Society)