Table 2.
Role of microRNA in glioma biology.
| MicroRNA | |||||
|---|---|---|---|---|---|
| mi-RNA | Target gene | References | mi-RNA | Target gene | References |
| Down-regulation | |||||
| miR-873 | GLI1, Bcl-2, | Chen et al. (2015), Zhang J.-S. et al. (2017) | miR-152 | Runx2 | Zhang P. et al. (2017) |
| miR-34a | PD-L1 | Wang and Wang (2017) | miR-152-3p | NF2 | Sun J. et al. (2017) |
| miR-373 | CD44, TGFBR2 | Wei F. et al. (2016), Jing et al. (2017) | miR-153 | Irs-2 | Xu et al. (2011), Ghasemi et al. (2016) |
| miR-146a | Notch | Hu et al. (2016) | miR-181 | VCAM-1, Bcl-2 | Chen et al. (2010), Liu et al. (2017) |
| miR-7 | EGFR, PI3K/ATK, Raf/MEK/ERK | Liu X. et al. (2013), Liu et al. (2014) | miR-184 | FIH1, SND1 | Yuan et al. (2014), Emdad et al. (2015) |
| miR-128 | RhoE | Shang et al. (2016b) | miR-204 | IGFBP2 | Chen et al. (2016) |
| miR-195 | E2F3, Cyclosporin | Zhang Q.-Q. et al. (2012), Yilaz Susluer et al. (2015) | miR-218 | Robo1, E2F2, NF-kappaB | Xia et al. (2013), Zhang et al. (2015), Gu et al. (2016) |
| miR-124 | SCP1, Capn4 | Cai et al. (2016), Sun A. G. et al. (2017) | miR-326 | SMO | Du et al. (2015) |
| miR-137 | PTP4A3, CSE1L | Li K. K. et al. (2013), Wang et al. (2016) | miR-410 | MET | Chen et al. (2012) |
| miR-15b | Cyclin D1, NRP-2 and MMP-3 | Zheng et al. (2013), Sun et al. (2014) | miR-483-5p | ERK1 | Wang et al. (2012) |
| miR-16-1 | Zyxin | Li X. et al. (2013) | miR-125b | Connexin43 | Jin et al. (2013) |
| miR-31 | radixin | Hua et al. (2012) | miR-138 | Immune, | Wei J. et al. (2016) |
| miR-101 | COX-2, | Ma et al. (2016) | miR-145 | ABCG2, SOX9, adducin 3 | Rani et al. (2013), Shi et al. (2014) |
| miR-491-5p | EGFR, CDK6 and Bcl-xL | Li et al. (2015) | miR-149 | Akt/mTOR, signaling, | Xue et al. (2015) |
| miR-491-3p | IGFBP2 and CDK6 | Li et al. (2015) | |||
| Up-regulation | |||||
| miR-21 | Spry2 | Kwak et al. (2011) | miR-18a | Neogenin, zonula occluden-1, claudin-5, and occludin | Song et al. (2014), Zhao et al. (2015) |
| miR-26a | PTEN, TUG1 | Huse et al. (2009), Li et al. (2016) | miR-20a | TIMP-2, LRIG1 | Wang et al. (2015), Wei et al. (2015) |
| miR-10b | RHOC | Dong et al. (2012) | miR-23b | TUSC7, TFAM | Jiang et al. (2013), Shang et al. (2016a) |
| miR-30e | CBL-B | Kwak et al. (2015) | miR-93 | integrin-beta8, IL-8, | Fang et al. (2011), Fabbri et al. (2015) |
| miR-221/222 | TIMP2, PTPμ, Cx43, P27Kip1, | Zhang C. et al. (2009), Hao et al. (2012), Quintavalle et al. (2012), Yang et al. (2015) | miR-125b-2 | mitochondrial pathway of apoptosis, | Shi et al. (2012) |
| miR-17-92 | CTGF | Ernst et al. (2010) | miR-296-3p | EAG1 | Bai et al. (2013) |
| miR-9/9* | CAMTA1 | Schraivogel et al. (2011) | miR-451 | SMAD | Gal et al. (2008) |
miR-9* is the complementary sequence of miR-9.