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. 2018 Nov 8;2018:6808934. doi: 10.1155/2018/6808934

Figure 6.

Figure 6

MAVS is dispensable for survival and cytokine induction during influenza infection. MAVS KO and littermate WT mice were intranasally inoculated with IAV at 1000 pfu/mouse. Mortality (a) and body weights (b) were monitored daily. Body weight data were normalized to each mouse's starting body weight. Data are expressed as mean ± standard deviation (n = 18 for MAVS KO mice; n = 19 for WT mice). (c) PRR and cytokine mRNA induction in mouse lung. Mice were infected with 300 pfu of the IAV PR8 strain. Mock-treated mice were inoculated with PBS. At day 6 postinfection, the mice were sacrificed and lung tissues were collected for RNA preparation. The mRNA levels were assessed by qRT-PCR and normalized β-actin. Data are expressed as mean ± SEM of fold increase (n ≥ 3 per group). For clarity, we only show significant differences (∗ p < 0.05) between the PR8-infected MAVS KO group and the PR8-infected WT group. p value was calculated from the ΔΔCt values from different experimental groups.