Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Nov 15;12:754. doi: 10.3389/fnins.2018.00754

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Vandenberghe, Souedet, Hérard, Ayral, Letronne, Balbastre, Sadouni, Hentraye, Dhenain, Frouin, Lambert and Delzescaux.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Clusters detection and anatomical localization. (A) Permutation-based cluster mass distribution under the null-hypothesis. The red line corresponds to the significance threshold at a risk α = 0.05. (B) 3D mesh representation of the two clusters where the Aβ load is reduced in APP_{Swe, Ind}-Cre-ADAM30 mice compared to APP_{Swe, Ind}-ADAM30. Green corresponds to the cortical cluster and purple corresponds to the hippocampal cluster. (C–F) Top: T statistic values within the clusters are shown in blue and overlaid with the anatomical template at selected coronal levels of the brain. Bottom: the MICe brain atlas at the same coronal levels. Clusters are localized in (C) the retrosplenial area of the cortex (*), the lateral septal nucleus (°), (D) the cingulate area of the cortex and (E,F) the dentate gyrus of the hippocampal region (#).