Table 1.
Effect of the root extract of U. chamae on blood glucose (mg/dl) in alloxan-induced diabetes mellitus and percentage reduction in blood glucose (%).
| Days | Control (2% acacia) | Glibenclamide (71 µg/kg) | Pioglitazone (429 µg/kg) | UC (100 mg/kg) | UC (250 mg/kg) | UC (400 mg/kg) | Diabetic untreated |
|---|---|---|---|---|---|---|---|
| 0 | 86.75 ± 2.36 | 76.00 ± 3.22 | 83.33 ± 9.20 | 88.33 ± 3.76 | 71.33 ± 3.76 | 77.67 ± 4.26 | 65.33 ± 5.90 |
| 1 | 91.75 ± 1.93 | 357.7 ± 28.30∗ | 352.3 ± 9.40∗ | 359.0 ± 16.10∗ | 337.3 ± 6.70∗ | 501.7 ± 56.30∗ | 264.0 ± 5.80∗ |
| 3 | 82.00 ± 3.20 | 222.3 ± 51.40∗ (37.85) | 239.0 ± 38.40∗ (32.16) | 284.7 ± 22.40∗ (20.70) | 270.7 ± 18.8∗ (19.75) | 280.3 ± 8.30∗ (44.13) | 272.0 ± 2.00∗ (−3.03) |
| 5 | 84.00 ± 3.00 | 189.0 ± 48.80 (47.16) | 173.7 ± 35.80 (50.70) | 198.7 ± 64.30 (44.65) | 94.0 ± 7.50 (72.13) | 157.0 ± 61.10 (68.71) | 282.3 ± 1.50∗ (−6.93) |
| 7 | 78.25 ± 4.27 | 132.0 ± 16.80 (63.10) | 245.0 ± 59.81∗ (30.46) | 100.0 ± 11.68 (72.14) | 71.67 ± 9.17 (78.75) | 61.67 ± 1.86 (87.71) | 288.7 ± 0.88∗ (−9.36) |
| 9 | 90.25 ± 3.10 | 117.0 ± 11.90 (67.29) | 275.3 ± 48.40∗ (21.86) | 91.67 ± 13.60 (74.47) | 70.33 ± 8.70 (79.15) | 58.33 ± 6.40 (88.37) | 297.7 ± 1.20∗ (−12.77) |
| 11 | 84.75 ± 2.50 | 109.3 ± 10.30 (69.44) | 202.3 ± 70.50 (42.58) | 90.33 ± 9.20 (74.84) | 73.0 ± 4.00 (78.36) | 50.33 ± 7.40 (89.97) | 305.3 ± 4.80∗ (−15.64) |
| 13 | 83.50 ± 4.90 | 100.0 ± 7.50 (72.04) | 145.7 ± 77.70 (58.64) | 79.0 ± 10.70 (77.99) | 68.33 ± 2.00 (79.74) | 55.0 ± 7.60 (89.04) | 312.7 ± 9.20∗ (−18.45) |
| 15 | 79.75 ± 3.50 | 93.0 ± 5.60 (74.00) | 158.3 ± 59.30 (55.07) | 75.0 ± 10.00 (79.11) | 72.33 ± 4.30 (78.56) | 59.67 ± 6.40 (88.11) | 318.7 ± 11.30∗ (−20.72) |
∗Significant difference (p < 0.05; n=5) between the mean ± SEM of test groups vs. control. UC: Uvaria chamae.