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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Neurobiol Dis. 2018 Sep 26;121:138–147. doi: 10.1016/j.nbd.2018.09.020

Figure 5. CypD deficiency improves cognitive function in 5×FAD mice.

Figure 5.

(a) Swimming traces for probe test after 11 day learning at Morris water maze for nonTg, Ppif−/− mice and their Aβ-expressing counterparts at young and old ages. (b) 5×FAD mice demonstrated impaired learning ability to locate the hidden platform (in an age-dependent manner), which was protected in CypD deficient AD mice. *P<0.05 vs other groups. (c) Mice in different groups did not display any difference in their swimming speeds. *P<0.05 vs other groups. n=6 for each group. Error bars represent s.e.m.