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. Author manuscript; available in PMC: 2019 Nov 14.
Published in final edited form as: Cell Host Microbe. 2018 Nov 14;24(5):717–730.e5. doi: 10.1016/j.chom.2018.10.012

Figure 3. Naturally selected substitutions in C117 E2 confer partial resistance to autologous plasma antibodies and autologous bNAbs.

Figure 3.

(A) All substitutions arising longitudinally in E2 over the course of C117 infection. Dots indicate homology with the D17–1a53 (T/F) sequence. (B-D) Binding in an ELISA to longitudinal C117 E1E2 proteins (left) or neutralization of HCVpp expressing longitudinal C117 E1E2 proteins (right) by C117 D388 plasma IgG (B), HEPC3 (C), or HEPC98 (D) All assays were performed in duplicate, and values are means +/− SD. (See Fig S5 for additional independent experiments).