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. Author manuscript; available in PMC: 2019 Nov 14.
Published in final edited form as: Cell Host Microbe. 2018 Nov 14;24(5):717–730.e5. doi: 10.1016/j.chom.2018.10.012

Figure 7. BNAb resistance/loss of fitness substitutions selected in C117 and C110 E2 overlap with HEPC3 and HEPC74 binding epitopes, as well as the CD81 binding site.

Figure 7.

Binding and resistance substitution positions are indicated with colored spheres superimposed on the HEPC3-E2ecto1b09 structure. E2 structure is gray. (A) Main chain atoms of critical binding residues and/or contact residues of HEPC3 (yellow spheres) and C117 resistance/loss of fitness substitutions (magenta spheres). (B) Main chain atoms of critical binding residues and/or contact residues of HEPC74 (orange spheres) and C110 resistance/loss of fitness substitutions (blue spheres). (C) Main chain atoms of critical binding residues of CD81LEL (cyan spheres) and resistance/loss of fitness substitutions of C117 (magenta) or C110 (blue). Resistance/loss of fitness substitutions are indicated that fall at contact or critical binding residues (**) or within two amino acids of a contact or critical binding residue (*).