Table 3.
Optimal cutoff point of each study marker, sensitivity, specificity and AUC values in predicting response to EGFR TKI
| Parameter | Cutoff | Sensitivity, % (95% CI) | Specificity,% (95% CI) | AUC, % (95% CI) |
|---|---|---|---|---|
|
| ||||
| WBC, 109/L | 9.0 | 48.2 | 78.4 | 0.699 |
| (37.3–59.3) | (69.2–86.0) | (0.623–0.775) | ||
| PLT, 109/L | 324.0 | 32.9 | 77.5 | 0.548 |
| (23.1–44.0) | (68.1–85.1) | (0.464–0.632) | ||
| NLR | 2.96 | 71.8 | 90.2 | 0.873 |
| (60.5–81.4) | (82.6–95.5) | (0.821–0.926) | ||
| MLR | 0.38 | 54.1 | 86.3 | 0.762 |
| (44.7–67.6) | (77.5–92.4) | (0.691–0.832) | ||
| PLR | 189.8 | 49.4 | 78.4 | 0.689 |
| (38.4–60.5) | (69.2–86.0) | (0.613–0.766) | ||
Abbreviations: AUC, area under the curve; WBC, white blood cell; PLT, platelet; NLR, neutrophil to lymphocyte ratio, MLR, monocyte to lymphocyte ratio; PLR, platelet to lymphocyte ratio; TKI, tyrosine kinase inhibitor.