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. 2018 Nov 16;46(12):e1160–e1166. doi: 10.1097/CCM.0000000000003434

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Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine and Wolters Kluwer Health, Inc.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 3. — Impact of fixed change in mean intracranial pressure (ICP) profile over 6 hr when cerebral autoregulation is intact and Paco₂ is 40 mm Hg. Paired graphs with input ICP profiles (A) and output cerebral perfusion pressure (CPP) ICP-to-blood pressure (BP) Fisher-transformed Pearson’s correlation (PR_x) plots before final curve fitting (the BP profile is the same in all simulations). A, The effect of injection of fluid into the cerebrospinal fluid space at six different rates (0.0–0.05 mL/s) to raise mean ICP to six constant levels (10, 15, 20, 25, 30, and 35 mm Hg). B, Output PR_x-plots for profiles in (A) showing shift similar to that seen with fixed alteration in BP (Fig. 2B for comparison; for results of final mathematical transformation to calculate optimal CPP, see Table S1, Supplemental Digital Content 3, http://links.lww.com/CCM/E36).