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. 2018 Nov 16;46(12):e1160–e1166. doi: 10.1097/CCM.0000000000003434

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Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine and Wolters Kluwer Health, Inc.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 5. — Impact of escalation in intracranial pressure (ICP) profile over 6 hr to a terminal plateau when cerebral autoregulation is intact and Paco₂ is 40 mm Hg. Paired graphs with input ICP profiles (A) and output cerebral perfusion pressure (CPP) ICP-to-blood pressure (BP) Fisher-transformed Pearson correlation (PR_x) plots before final curve fitting (the BP profile is the same in all simulations). A, Five patterns of escalation in ICP (color-coding similar to Fig. 3, see text for details). B, Output PR_x-plots for profiles in A, showing shift in curves (for results of final mathematical transformation to calculate optimal CPP, see Table S1, Supplemental Digital Content 3, http://links.lww.com/CCM/E36).