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Crystal structure of NQO1 R139W. Panel A: Cartoon model of the superposition of NQO1 and NQO1 R139W with the arginine and tryptophan residue (right) and the FAD (left) shown as a stick model. Panel B: Cartoon model of the NQO1 R139W homodimer with the tryptophan residue and the FAD shown as a stick model. Panel C: Fo − Fc omit electron density contoured at 3σ for the isoalloxazine moiety of FAD bound to one of the subunits (left) and for tryptophan 139 (right).
