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. Author manuscript; available in PMC: 2018 Nov 22.
Published in final edited form as: FEBS J. 2013 Jul 31;280(17):4323–4334. doi: 10.1111/febs.12421

Fig. 1.

Fig. 1

Mechanisms of differentiation suppression in rhabdomyosarcoma. Middle text represents transcriptional, epigenetic and cytokine signaling converge on the myogenic differentiation state of this sarcoma. Shown on left side are examples of embryonal rhabdomyosarcoma with less differentiation (as seen at diagnosis), and on the right are examples of embryonal rhabdomyosarcoma with mature rhabdomyoblasts whose eosinophilic cytoplasm contains myofibrillary proteins (as often seen at completion of therapy). Photomicrographs kindly provided by Drs. David Parham and Atiya Mansoor.