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Examination for the primary diagnosis. (A) A large accumulation of leukemic cells in the bone marrow. (B) A G-banded karyotype of bone marrow analysis showing a Philadelphia chromosome. (C) The fusion of BCR/ABL1 loci was detected by fluorescence in situ hybridization using the Vysis Extra Signal probeyielding red-green fusion signal. (D) Detection of BCR/ABL1 fusion gene copy number by real-time quantitative polymerase chain reaction.
