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. Author manuscript; available in PMC: 2019 Nov 21.
Published in final edited form as: Neuron. 2018 Oct 11;100(4):831–845.e7. doi: 10.1016/j.neuron.2018.09.027

Figure 4: Ectopic growth of layer 6 apical dendrites into superficial layer 1 in Tbr1layer6 mutants.

Figure 4:

The endogenous tdTomato fluorescence (red) in the SSCx of Control (Ntsr1-cre::tdTomatof/+) (A-C), Tbr1layer6 heterozygous (Tbr1f/+::Ntsr1-cre::tdTomatof/+) (A´-C´), and Tbr1layer6 homozygous mutants (Tbr1f/f::Ntsr1-cre::tdTomatof/+) (A´´-C´´). These mice had the Ntsr1cre::tdTomatof/+ alleles to label the layer 6 cell bodies and their dendrites. Changes in the dendritic patterning of layer 6 neurons were examined at P3 (A-A´´), P21 (B-B´´) and P56 (CC´´). White arrowheads indicate some of the apical dendrites extending through layers 2/3 to layer 1 in Tbr1layer6 mutants. Orange arrowheads indicates a group of apical dendrites that only extend to layers 2/3. Cortical layers are labelled. Scale bar: 50μm. See also Figure S4.