Table 2.

Effect of two kinds of insulin lispro 25 therapy with metformin on blood glucose variability

Treatment	Prandilin 25	Humalog mix 25	F value	p value
24hMBG (mmol/l)	7.43 ± 1.10	7.30 ± 1.17	0.680	0.411
24hSDBG (mmol/l)	1.74 ± 0.75	1.61 ± 0.79	0.862	0.355
24hMAGE (mmol/l)	4.14 ± 1.84	3.86 ± 1.98	0.839	0.361
CV	0.23 ± 0.08	0.22 ± 0.09	0.391	0.532
MAXBG (mmol/l)	12.25 ± 2.85	11.78 ± 2.81	1.144	0.287
MINBG (mmol/l)	4.45 ± 1.01	4.47 ± 1.30	0.001	0.973
LAGE (mmol/l)	7.80 ± 2.98	7.31 ± 3.12	1.009	0.317
AUC < 3.9	0.00 (0.00, 0.21)	0.00 (0.00, 1.05)	0.479	0.494
< 3.9 time (%)	0.00 (0.00, 0.69)	0.00 (0.00, 2.34)	0.211	0.646
AUC3.9–10	4595.34 ± 1007.33	4418.87 ± 1140.89	0.215	0.646
≥ 3.9 and ≤ 10 time (%)	86.35 ± 12.86	87.10 ± 13.33	0.191	0.662
AUC > 10	101.90 (0.00, 497.85)	64.20 (0.00, 400.05)	0.351	0.558
> 10 time (%)	7.46 (0.00, 17.36)	7.12 (0.00, 15.10)	0.448	0.504

Data are mean ± SD for normally distributed and continuous variables and median (interquartile range) for non-normally distributed variables

MBG mean glucose concentration (mmol/l), SDBG standard deviation of the MBG (mmol/l), MAGE mean amplitude of glycemic excursion (mmol/l), CV coefficient of variation, MAXBG maximum blood glucose, MINBG minimum blood glucose, LAGE large amplitude of glycemic excursion, AUC < 3.9 decremental area over the curve of glucose concentrations < 3.9 mmol/l (mmol/l per day), < 3.9 time percentage of the time spent on glucose concentrations < 3.9 mmol/l, AUC3.9–10 incremental area under the curve of glucose concentrations between 3.9 and 10 mmol/l (mmol/l per day), ≥ 3.9 and ≤ 10 times percentage of the time spent on glucose concentrations between 3.9 and 10 mmol/l, AUC > 10 incremental area under the curve of glucose concentrations > 10.0 mmol/l (mmol/l per day), > 10 times percentage of time spent on glucose concentrations above 10.0 mmol/l