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. 2018 Nov 22;8:17252. doi: 10.1038/s41598-018-35092-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Many genes show reduced pleiotropy when currency metabolites are made freely available. The bar chart shows the percentage of previously pleiotropic genes with reduced pleiotropy in response to the free availability of different currency metabolites. Abbreviations: Adenosine triphosphate (ATP); Cytidine triphosphate (CTP); Guanosine triphosphate (GTP); Uridine triphosphate (UTP); Inosine triphosphate (ITP); Nicotinamide adenine dinucleotide (NADH); Nicotinamide adenine dinucleotide phosphate (NADPH); Flavin adenine dinucleotide reduced (FADH2); Reduced flavin mononucleotide (FMNH2); Ubiquinol-8 (Q8H2); Menaquinol 8 (MQL8); 2-Demethylmenaquinol 8 (DMMQL8); Acetyl-CoA (ACCOA); L-Glutamate (GLU).