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. 2018 Nov 22;8:17262. doi: 10.1038/s41598-018-35579-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Functional validation of the experimental models. Results of anxiety/depressive-like behavior tests were obtained 3 months after irradiation in mice. The elevated plus maze test, the marble burying test and the forced swimming test (from top to bottom) were performed during three consecutive days. Results are expressed as mean ± sem of n = 10–22 animals for exposed groups and n = 33 for controls. For each behavioral test, there was no statistical difference between the control groups, therefore we pooled them (n = 33) and the different experiments. The left panel shows the effect of brain irradiation on behavioral functions in comparison with control mice (*p < 0.05 vs controls). In the right panel, behavioral functions in control mice, in brain irradiated mice and in dorsal DG irradiated mice in comparison with behavioral functions after ventral DG irradiation in mice is showed (*p < 0.05 vs ventral DG irradiated mice; NS is used to show non-significant difference vs ventral DG irradiated mice).