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. 2018 Nov 22;8:17259. doi: 10.1038/s41598-018-35332-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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High RGS2 expression is correlated with metastasis and poor prognosis. (a) Assessment of RGS2 staining in relation to metastasis in patients with advanced PC. Metastasis positive (n = 27) and negative (n = 11). (b) Representative images of RGS2 staining of matched specimens of M0 and M1. Bar represents 100 µm. Kaplan-Meier curves and log rank of (c) cancer specific survival and high respective low RGS2 expression (p = 0.041, by Log-rank test) and (d) cancer specific survival and M-stage (n_M1 = 24, n_M0 = 12, n_Mx = 7, p = 0.018, by Log-rank test).