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. 2018 Nov 22;8:17255. doi: 10.1038/s41598-018-35610-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Genes regulated by HSF1 in LK-treated CGNs. (A) A total of 425 genes were regulated by HSF1 in LK compared to the control, GFP LK. As shown in the Venn diagram, 168 of these DEGs were also found altered by LK treatment in GFP control sample (vs. GFP HK). (B) Gene Ontology analysis showed that the 425 HSF1 target genes were involved in various biological processes, including protein folding, protein processing in endoplasmic reticulum, and intracellular signal transduction. The top protein network that these DEGs participate in functions in cellular assembly and organization, cellular compromise, and post-translational modification (C). Red color represents upregulation by HSF1 while green color indicates downregulation. The color intensity shows the degree of level change. Proteins in white shapes do not belong to our data set but have relationships with our proteins in the network.