Table 3.
Performance of VIA examination and HPV Xpert test algorithms for detection of high-grade disease.
| Screening Algorithm | High-Grade Disease |
Percentage % |
||||||
|---|---|---|---|---|---|---|---|---|
| Positive n (%) | Negative n (%) | Sensitivity [95% CI] | Specificity [95% CI] | PPV [95% CI] | NPV [95% CI] | |||
| Algorithm 1 (n = 462) |
POSITIVE | VIA + | 17 (3.7) | 80 (17.3) |
51.5 [33.5–69.2] |
81.4 [77.3–84.9] |
17.5 [10.6–26.6] |
95.6 [93.0–97.5] |
| NEGATIVE | VIA - | 16 (3.5) | 349 (75.5) | |||||
| Algorithm 2 (n = 527) |
POSITIVE |
Any hrHPV + (hrHPV test on self-collected specimen) |
33 (6.3) | 64 (12.1) |
91.7 [77.5–98.2] |
87.0 [83.7–89.8] |
34.0 [24.7–44.3] |
99.3 [98.0–99.9] |
| NEGATIVE |
Any hrHPV – (hrHPV test on self-collected specimen) |
3 (0.6) | 427 (81.0) | |||||
|
Algorithm 3 (n = 529) |
POSITIVE |
Any hrHPV + (hrHPV test on clinician-collected specimen) |
33 (6.2) | 48 (9.1) |
91.7 [77.5–98.2] |
90.3 [87.3–92.7] |
40.7 [29.9–52.2] |
99.3 [98.1–99.9] |
| NEGATIVE |
Any hrHPV – (hrHPV test on clinician-collected specimen) |
3 (0.6) | 445 (84.1) | |||||
|
Algorithm 4 (n = 515) |
POSITIVE |
Any hrHPV + and VIA + (hrHPV test on self-collected specimen) |
15 (2.9) | 18 (3.5) |
45.5 [28.1–63.6] |
96.3 [94.2–97.8] |
45.5 [28.1–63.6] |
96.3 [94.2–97.8] |
| NEGATIVE |
Any hrHPV – or Any hrHPV + and VIA - (hrHPV test on self-collected specimen) |
18 (3.5) | 464 (90.1) | |||||
Algorithm 1 versus Algorithm 2; sensitivity p < 0.01, specificity p = 0.02, PPV p < 0.01, NPV p < 0.01.
Algorithm 1 versus algorithm 3; sensitivity p < 0.01, specificity p < 0.01, PPV p < 0.01, NPV p < 0.01.
Algorithm 1 versus algorithm 4; sensitivity p = 0.62, specificity p < 0.01, PPV p < 0.01, NPV p = 0.63.
Algorithm 2 versus algorithm 4; sensitivity p < 0.01, specificity p < 0.01, PPV p = 0.24, NPV p < 0.01.