Table 6.
Results of “ChEA 2016” analysis for 96 ≪stemness genes≫ showing elevated expression in TAMRA+ Krebs-2 carcinoma cells relative to TAMRA− cells, with regard to enrichment with SOX2/OCT4/POU5F1/NANOG/KLF4/c-MYC binding sites.
| TrF | Overlap | P-value | Genes |
|---|---|---|---|
| SOX2 | 21/2564 | 0.009245 | Arg2; Crabp2; Ankrd22; Pde4d; Gata6; Cldn1; Dusp23; Myo1b; Nt5e; Fmnl2; Rab15; Ppap2b; Aldh1a1; Rragd; Pdk4; Maged2; Asb4; S100a14; Gas6; Cd55; Fgfr1 |
| SOX2 | 17/1991 | 0.013342 | Il10; Gstm3; Tcf7l2; Fblim1; Wnt5a; Alox15; Clec11a; Igf1; Tnfrsf13c; Nt5e; Adrb3; Ppap2b; Kcnq2; Rragd; Blnk; Asb4; Fgfr1 |
| SOX2 | 16/2000 | 0.028265 | Il10; Serpinb2; Itln1; Nfatc2; Prg4; Dock10; Selp; Per2; Dusp23; Col3a1; Myo1b; Fmnl2; Tnn; Kcnq2; Lhx4; Cd55 |
| SOX2 | 8/1278 | 0.270262 | Per2; Tcf7l2; Tal1; Rab15; Rragd; Maged2; Pvrl1; Fgfr1 |
| SOX2 | 14/2000 | 0.096132 | Gstm3; Fblim1; Clec11a; Gata6; Itln1; Nfatc2; Cyp7a1; Per2; Lass4; Aldh1a1;Pdk4;Blnk; Gas6; Atp6v0d2 |
| SOX2 | 14/2000 | 0.096132 | Il10; Abca1; Cd5l; Abca9; Cacna1d; Igf1; Cp; Thpo; Rab37; Slco4a1; Tubb1; Maged2; Atp6v0d2; Cd200 |
| SOX2 | 13/2000 | 0.160414 | Il10; Tcf7l2; Aldh1l1; Arg2; Wnt5a; Nfatc2; Cacna1d; Cp; Tal1; Grb10; Lhx4; Acpp; Cd55 |
| SOX2 | 5/863 | 0.399596 | Per2; Gata6; Gdf6; Ltbp1; Itga9 |
| SOX2 | 19/3319 | 0.235257 | Il10; Gstm3; Tcf7l2; Fblim1; Alox15; Clec11a; Wnt5a; Igf1; Tnfrsf13c; Nt5e; Adrb3; Slco4a1; Ppap2b; Kcnq2; Rragd; Blnk; Asb4; Fgfr1; Itga9 |
| SOX2 | 2/497 | 0.692959 | Per2; Myo1b |
| SOX2 | 3/785 | 0.732379 | Il10; Per2; Ppap2b |
| SOX2 | 19/3420 | 0.278900 | Pde4d; Hpn; Nfatc2; Cacna1d; Gdf6; Abca13; Ltbp1; Rasgrp3; Dock10; Fmnl2; Bmper; Tnn; Slco4a1; Rab37; Kcnq2; Aldh1a1; Lhx4; Pvrl1; Ccr3 |
| SOX2 | 10/2000 | 0.495379 | Aldh1l1; Adamts2; Bmper; Rab15; Eef1a2; Hpn; Tubb1; Abca9; Gpha2; Pvrl1 |
| OCT4 | 20/2000 | 0.001144 | Il10; Serpinb2; Wnt5a; Itln1; Prg4; Igf1; Nts; Abca13; Dock10; Selp; Per2; Dusp23; Col3a1; Myo1b; Adamts2; Tnn; Col6a2; Grb10; Lhx4; Cd55 |
| OCT4 | 16/2000 | 0.028265 | Il10; Serpinb2; Itln1; Nfatc2; Prg4; Dock10; Selp; Per2; Dusp23; Col3a1; Myo1b; Fmnl2; Tnn; Kcnq2; Lhx4; Cd55 |
| OCT4 | 13/1992 | 0.157087 | Il10; Gstm3; Tcf7l2; Wnt5a; Alox15; Nfatc2; Nt5e; Adrb3; Kcnq2; Rragd; Asb4; Pvrl1; Fgfr1 |
| OCT4 | 13/2000 | 0.160414 | Tnxb; Cacna1d; Slc2a4; Comp; Adamts2; Tdo2; Adrb3; Slco4a1; Trpv4; Kcnq2; Rragd; Pvrl1; Itga9 |
| OCT4 | 7/2000 | 0.856909 | Tcf7l2; Eef1a2; Hpn; Grb10; Igf1; Acpp; Rasgrp3 |
| POU5F1 | 12/1550 | 0.067193 | Adamts2; Crabp2; Bmper; Thpo; Adrb3; Pde4d; Rragd; Pdk4; Cacna1d; Mycbpap; Asb4; Fgfr1 |
| POU5F1 | 6/622 | 0.078803 | Nt5e; Tal1; Mmp2; Gata6; Maged2; Fgfr1 |
| POU5F1 | 12/2109 | 0.311132 | Il10; Myo1b; Nt5e; Fmnl2; Adrb3; Fblim1; Tal1; Ppap2b; Cacna1d; Maged2; Asb4; Igf1 |
| POU5F1 | 3/753 | 0.705916 | Il10; Per2; Cyp26a1 |
| POU5F1 | 1/567 | 0.937187 | Slco4a1 |
| POU5F1 | 1/555 | 0.933343 | Prok2 |
| POU5F1 | 2/559 | 0.753373 | Cyp26a1; Abca13 |
| POU5F1 | 18/4232 | 0.755639 | Il10; Gstm3; Tcf7l2; Fblim1; Alox15; Wnt5a; Nfatc2; Tnfrsf13c; Nt5e; Adrb3; Slco4a1; Ppap2b; Kcnq2; Rragd; Asb4; Pvrl1; Fgfr1; Itga9 |
| NANOG | 15/1989 | 0.051785 | Tcf7l2; Wnt5a; Igf2; Igf1; Tnfrsf13c; Serpinb1a; Nt5e; Adrb3; Ppap2b; Kcnq2; Rragd; Blnk; Asb4; Pvrl1; Fgfr1 |
| NANOG | 14/2000 | 0.096132 | Il10; Serpinb2; Itln1; Nfatc2; Prg4; Dock10; Selp; Dusp23; Col3a1; Myo1b; Fmnl2; Tnn; Lhx4; Cd55 |
| NANOG | 19/3052 | 0.137575 | Tcf7l2; Wnt5a; Igf2; Igf1; Tnfrsf13c; Ltbp1; Serpinb1a; Nt5e; Adrb3; Rab15; Slco4a1; Ppap2b; Kcnq2; Rragd; Blnk; Asb4; Pvrl1; Itga9; Fgfr1 |
| NANOG | 13/2000 | 0.160414 | Il10; Tcf7l2; Aldh1l1; Arg2; Wnt5a; Nfatc2; Cacna1d; Cp; Tal1; Grb10; Lhx4; Acpp; Cd55 |
| NANOG | 9/1686 | 0.420900 | Tcf7l2; Tdo2; Rab15; Tal1; Mmp2; Gata6; Lhx4; Cldn1; Fgfr1 |
| NANOG | 5/840 | 0.377515 | Clec11a; Blnk; Igf1; Acpp; Itga9 |
| NANOG | 16/3520 | 0.636674 | Pde4d; Igf1; Cp; Lass4; Col3a1; Myo1b; Nt5e; Bmper; Adrb3; Rab37; Ppap2b; Pdk4; Grb10; Pvrl1; Fgfr1; Itga9 |
| NANOG | 11/1908 | 0.307350 | Tcf7l2; Serpinb1a; Adrb3; Fblim1; Ppap2b; Rragd; Igf2; Blnk; Igf1; Itga9; Fgfr1 |
| NANOG | 1/344 | 0.811672 | Igf2 |
| NANOG | 2/542 | 0.737895 | Serpinb1a; Dusp23 |
| NANOG | 3/1232 | 0.940192 | Slco4a1; Blnk; Igf1 |
| NANOG | 8/2000 | 0.756029 | Tcf7l2; Dusp23; Arg2; Tal1; Prok2; Igf1; Gpha2; Ccr3 |
| KLF4 | 12/1211 | 0.013033 | Col3a1; Adamts2; Nt5e; Fblim1; Ankrd22; Gata6; Prok2; Slc2a4; Ltbp1; Cd200; Ccr3; Itga9 |
| KLF4 | 16/2000 | 0.028265 | Il10; Serpinb2; Itln1; Nfatc2; Prg4; Dock10; Selp; Per2; Dusp23; Col3a1; Myo1b; Fmnl2; Tnn; Slco4a1; Lhx4; Cd55 |
| KLF4 | 13/2000 | 0.160414 | Il10; Gstm3; Tcf7l2; Chrm1; Fblim1; Gata6; Cyp26a1; Myo1b; Rab37; Slco4a1; Ppap2b; Pvrl1; Cd55 |
| KLF4 | 8/1502 | 0.433701 | Cyp26a1; Bmper; Tal1; Ppap2b; Gata6; Igf2; S100a14; Cd55 |
| KLF4 | 6/2444 | 0.982047 | Per2; Lass4; Bmper; Col6a2; Tnfrsf13c; Acpp |
| KLF4 | 7/1700 | 0.717649 | Myo1b; Lass4; Slco4a1; Igf2; Nfatc2; Pvrl1; Cd55 |
| KLF4 | 10/2000 | 0.495379 | Comp; Myo1b; Lass4; Slco4a1; Tal1; Pon1; Gata6; Grb10; Lhx4; Pvrl1 |
| CMYC | 16/2000 | 0.028265 | Il10; Serpinb2; Itln1; Nfatc2; Prg4; Dock10; Selp; Per2; Dusp23; Col3a1; Myo1b; Fmnl2; Tnn; Kcnq2; Lhx4; Cd55 |
| MYC | 14/2000 | 0.096132 | Ddx3y; Tnfrsf13c; Gdf6; Rasgrp3; Selp; Cyp26a1; Adamts2; Tal1; Rragd; Blnk; Asb4; Gas6; Pvrl1; Fgfr1 |
| MYC | 16/2979 | 0.354148 | Gstm3; Tcf7l2; Tnxb; Crabp2; Mmp2; Wnt5a; Gata6; Igf2; Igf1; Ltbp1; Adamts2; Thpo; Rab15; Asb4; Lhx4; Cd55 |
| MYC | 3/797 | 0.741816 | Blnk; Nfatc2; Tnfrsf13c |
| MYC | 2/3413 | 1.000000 | Per2; Adrb3 |
| MYC | 6/3868 | 0.999934 | Tcf7l2; Clec11a; Wnt5a; Grb10; Gata6; Gdf6 |
| MYC | 2/1458 | 0.994109 | Lass4; Fgfr1 |
| MYC | 2/746 | 0.877854 | Rab37; Prok2 |
| MYC | 4/1406 | 0.912685 | Mmp2; Ppap2b; Prok2; Tnfrsf13c |
| MYC | 11/2000 | 0.364090 | Ddx3y; Myo1b; Arg2; Slco4a1; Ankrd22; Hpn; Igf2; Grb10; Prg4; Igf1; Rasgrp3 |