Figure 1.

PEA prophylaxis delays the onset of symptoms and improves outcomes of old animals with E. coli meningoencephalitis. (A) Kaplan-Meier overall survival and (B) symptom-free survival curves after the intracerebral injection of 800 CFU E. coli K1/mouse in aged mice (n = 9/group, data from two independent experiments). (C) Median body weight loss until the first mouse died (28 h p.i.). Data from two independent experiments are shown as medians ± interquartile range (25th/75th percentile). Statistic analyses in (A,B) were performed by using the log-rank test, and in (C) by using the Mann–Whitney U-test after calculation of the individual AUCs of the weight loss 0–28 h p.i.