Figure 6.

PEA reduces AA serum levels and its subsequent oxidation into 20-HETE in aged mice with meningitis. (A) Concentrations of arachidonic acid (AA, in nmol/ml), and (B) levels of 20-hydroxyeicosatetraenoic acid (HETE, in pmol/ml) were lower in the serum of aged infected animals pre-treated with PEA than in infected mice pre-treated with vehicle (n = 10/group). Serum levels of PEA and PGE₂ were not significantly altered. ^*P < 0.05 between PEA and vehicle groups, using the Mann–Whitney U-test followed by Holm–Bonferroni correction for multiple testing.