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. 2018 Nov 16;9:2776. doi: 10.3389/fmicb.2018.02776

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Copyright © 2018 Han, Liu, Velkov, Lin, Zhu, Li, Yu, Zhou, Creek, Zhang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pathway analysis of significantly affected metabolites in A. baumannii AB090342 following the treatments with colistin, aztreonam alone and the combination at (A) 1 h, (B) 4 h, and (C) 24 h (FDR < 0.05, p < 0.05 and FC ≥ 2, one-way ANOVA). The pathway enrichment analysis was based on KEGG Pathway (http://www.genome.jp/kegg/pathway.html) with reference to Escherichia coli K-12. The figure was generated by MetaboAnalyst 4.0 (https://www.metaboanalyst.ca/).