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. 2018 Nov 16;9:2776. doi: 10.3389/fmicb.2018.02776

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Copyright © 2018 Han, Liu, Velkov, Lin, Zhu, Li, Yu, Zhou, Creek, Zhang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Perturbations of lipids and the related metabolites in A. baumannii AB090342. (A) Significantly perturbed major lipid classes following the treatment with colistin (COL, red), aztreonam (AZT, blue), and the combination (CA, green) at 1, 4, and 24 h. Lipid names were putatively identified based on the accurate mass. LM: lipid metabolism; FAs: fatty acids; GPLs: glycerophospholipids; SPLs: sphingolipids. (B) Significantly perturbed metabolites related to fatty acid and phospholipid synthesis and degradation after treated by colistin, aztreonam and the combination across all three time points. ^∗FDR < 0.05, p < 0.05 and log₂ FC ≥ 1 or ≤ –1 (one-way ANOVA).