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. 2018 Nov 16;11:418. doi: 10.3389/fnmol.2018.00418

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Copyright © 2018 Zieminska, Toczylowska, Diamandakis, Hilgier, Filipkowski, Polowy, Orzel, Gorka and Lazarewicz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Box and Whiskers plot of concentration of Glu (A), Gln (B) and GABA (C) in microdialysates of rat hippocampus collected at basal level and at 40 min post application of 100 mM KCl (KCl) measured using HPLC method. Results are presented as median (min÷max) values of tested amino acid concentration in μM. Results that are statistically significant vs. control represented by # and vs. basal level by &, p < 0.05. Number of rat pups: n = 10 (control), n = 11 (VPA) and n = 13 (THAL); # represents results statistically significant vs. control, p < 0.05, one-way ANOVA followed by Dunn’s correction; box containing 50% of results that fell in the range between 25% (bottom line) and 75% (top line), () median value, – outlier point per rat, ^∗ – extreme outlier point per rat.

Inline graphic — Box and Whiskers plot of concentration of Glu (A), Gln (B) and GABA (C) in microdialysates of rat hippocampus collected at basal level and at 40 min post application of 100 mM KCl (KCl) measured using HPLC method. Results are presented as median (min÷max) values of tested amino acid concentration in μM. Results that are statistically significant vs. control represented by # and vs. basal level by &, p < 0.05. Number of rat pups: n = 10 (control), n = 11 (VPA) and n = 13 (THAL); # represents results statistically significant vs. control, p < 0.05, one-way ANOVA followed by Dunn’s correction; box containing 50% of results that fell in the range between 25% (bottom line) and 75% (top line), () median value, – outlier point per rat, ^∗ – extreme outlier point per rat.