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Key players of host resistance to Salmonella: Lessons from humans and mice. Immunity to Salmonella builds up gradually during primary infection or subclinical exposure to the pathogens. Each level of resistance adds to the previous one. Therefore, full protection relies on the activity of the immune mechanisms from each one of the levels of resistance. Co-morbidities that undermine any of these levels of resistance would result in impaired overall resistance to iNTS disease.
