Table 2.
Range of increased relative risk of pancreatic cancer associated with specific syndromes as summarised by Chen et al[30] and Del Chiaro et al[31]
| Gene | Syndrome |
Increase relative risk vs general population |
|
| Chen et al[30] | Del Chiaro et al[31] | ||
| BRCA2 | Hereditary breast and ovarian cancer | 2.2-5.9 | |
| BRCA1 | 1.6-4.7 | ||
| STK11 | Peutz-Jeghers syndrome | 76.2-139.0 | 132.0 |
| PRSS1 | Hereditary pancreatitis | 53-87 | 50-70 |
| CDKN2A | Familial atypical multiple mole melanoma | 14.8-80.0 | 34-39 |
| MMR | Hereditary nonpolyposis colorectal cancer | 0.0-10.7 | 4.7 |