Table 4.
Univariate and multivariate Cox analysis for recurrence-free survival (n = 119)
| Variable | Univariate |
Multivariate |
||
|---|---|---|---|---|
| HR | p-value | HR | p-value | |
| Age (≥ 65 yr/< 65 yr) | 1.803 (0.791–4.114) | .161 | 2.163 (0.905–5.171) | .083 |
| Sex (male/female) | 1.672 (0.733–3.815) | .222 | - | - |
| Multiplicity (synchronous/solitary) | 2.939 (1.294–6.674) | .010 | - | .151 |
| T category (T3, 4/T2) | 2.993 (0.403–22.224) | .284 | - | - |
| N category (N1, 2/N0) | 4.378 (1.623–11.805) | .004 | 3.943 (1.457–10.670) | .007 |
| Vascular invasion (present/absent) | 3.658 (1.440–9.294) | .006 | 4.114 (1.527–11.081) | .005 |
| Lymphatic invasion (present/absent) | 3.096 (1.365–7.025) | .007 | - | .225 |
| Perineural invasion (present/absent) | 2.417 (0.952–6.136) | .063 | - | - |
| Tumor location (including right colon/left colon only) | 1.370 (0.509–3.690) | .534 | - | - |
| Chemotherapy (treated/not-treated) | 0.555 (0.130–2.369) | .427 | - | - |
| Surgery (extensive/simple) | 1.535 (0.456–5.169) | .489 | - | - |
| MSI (MSI-H/MSS, MSI-L) | 0.045 (0.000–63.182) | .401 | - | - |
| KRAS (mutant/wild type) | 1.776 (0.768–4.105) | .179 | - | - |
HR, hazard ratio; MSI, microsatellite instability; MSI-H, MSI-high; MSS, microsatellite-stable; MSI-L, MSI-low.