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. 2018 Nov 23;108(5):1069–1091. doi: 10.1093/ajcn/nqy097

FIGURE 2.

FIGURE 2

Dietary intake and blood concentrations of vitamin C and coronary heart disease: dose-response analyses. (A) Dietary vitamin C and coronary heart disease: linear dose-response analysis. The summary RR per 100 mg/d was 0.88 (95% CI: 0.79, 0.98, I2 = 65%, Pheterogeneity = 0.001, n = 11). (B) Vitamin C in blood and coronary heart disease: linear dose-response analysis. The summary RR per 50 µmol/L was 0.74 (95% CI: 0.65, 0.83, I2 = 0%, Pheterogeneity = 0.71, n = 4). (C) Dietary vitamin C and coronary heart disease: nonlinear dose-response analysis. There was evidence of nonlinearity between dietary vitamin C and coronary heart disease (Pnonlinearity < 0.0001). (D) Vitamin C in blood and coronary heart disease: nonlinear dose-response analysis. There was no evidence of nonlinearity for vitamin C in blood and coronary heart disease (Pnonlinearity = 0.49). Summary RRs and 95% CIs were calculated with the use of random-effects models, and the nonlinear dose-response analyses were conducted with the use of restricted cubic splines.