Skip to main content
. 2018 Nov 23;108(5):1069–1091. doi: 10.1093/ajcn/nqy097

FIGURE 3.

FIGURE 3

Dietary intake and blood concentrations of vitamin C and stroke: dose-response analyses. (A) Dietary vitamin C and stroke: linear dose-response analysis. The summary RR per 100 mg/d was 0.92 (95% CI: 0.87, 0.98, I2 = 68%, Pheterogeneity < 0.0001, n = 12). (B) Vitamin C in blood and stroke: linear dose-response analysis. The summary RR per 50 µmol/L was 0.70 (95% CI: 0.61, 0.81, I2 = 0%, Pheterogeneity = 0.41, n = 4). (C) Dietary vitamin C and stroke: nonlinear dose-response analysis. There was evidence of nonlinearity between dietary vitamin C and stroke (Pnonlinearity < 0.0001). (D) Vitamin C in blood and stroke: nonlinear dose-response analysis. There was no evidence of nonlinearity for vitamin C in blood and stroke (Pnonlinearity = 0.16). Summary RRs and 95% CIs were calculated with the use of random-effects models, and the nonlinear dose-response analyses were conducted with the use of restricted cubic splines.