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. 2018 Nov 23;108(5):1069–1091. doi: 10.1093/ajcn/nqy097

FIGURE 6.

FIGURE 6

Dietary intake and blood concentrations of vitamin C and mortality: dose-response analyses. (A) Dietary vitamin C and mortality: linear dose-response analysis. The summary RR per 100 mg/d was 0.89 (95% CI: 0.85, 0.94, I2 = 80%, Pheterogeneity < 0.0001, n = 14). (B) Vitamin C in blood and mortality: linear dose-response analysis. The summary RR per 50 µmol/L was 0.72 (95% CI: 0.66, 0.79, I2 = 48%, Pheterogeneity = 0.06, n = 8). (C) Dietary vitamin C and mortality: nonlinear dose-response analysis. There was evidence of nonlinearity between dietary vitamin C and mortality (Pnonlinearity < 0.0001). (D) Vitamin C in blood and mortality: nonlinear dose-response analysis. There was no evidence of nonlinearity for vitamin C in blood and mortality (Pnonlinearity = 0.90). Summary RRs and 95% CIs were calculated with the use of random-effects models, and the nonlinear dose-response analyses were conducted with the use of restricted cubic splines. SMHS, Shanghai Men's Health Study; SWHS, Shanghai Women's Health Study.