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. 2018 Nov 23;108(5):1069–1091. doi: 10.1093/ajcn/nqy097

FIGURE 8.

FIGURE 8

Dietary β-carotene and blood concentrations of β-carotene and coronary heart disease: dose-response analyses. (A) Dietary β-carotene and coronary heart disease: linear dose-response analysis. The summary RR per 5000 µg/d was 0.82 (95% CI: 0.68, 0.98, I2 = 45%, Pheterogeneity = 0.14, n = 4). (B) β-Carotene in blood and coronary heart disease: linear dose-response analysis. The summary RR per 25 µg/dL was 0.76 (95% CI: 0.62, 0.93, I2 = 22%, Pheterogeneity = 0.28, n = 4). (C) Dietary β-carotene and coronary heart disease: nonlinear dose-response analysis. There was evidence of nonlinearity between dietary β-carotene and coronary heart disease (Pnonlinearity = 0.006). (D) β-Carotene in blood and coronary heart disease: nonlinear dose-response analysis. There was evidence of nonlinearity for β-carotene in blood and coronary heart disease (Pnonlinearity = 0.002). Summary RRs and 95% CIs were calculated with the use of random-effects models, and the nonlinear dose-response analyses were conducted with the use of restricted cubic splines.