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. 2018 Nov 16;12:278. doi: 10.3389/fnbeh.2018.00278

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Copyright © 2018 Zaniboni, Pelarin, Baptista-de-Souza and Canto-de-Souza.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Effects of midazolam (0.5, 1.0, and 2.0 mg/kg, s.c.) or saline systemic injections (n = 89) on number of writhing in mice housed in dyads. Data are presented as mean ± SEM. ^∗p < 0.05 vs. respective saline group. #p < 0.05 vs. respective CS group. CNC, cagemate nerve constriction; CS, cagemate sham. (B) Effects of microinjection in insula (n = 57) of midazolam (3 and 30 nmol/0.1 μl) or saline on number of writhing in mice housed in dyads. Data are presented as mean ± SEM. #p < 0.05 vs. respective CS group. CNC, cagemate nerve constriction; CS, cagemate sham.